Piedmont, South Carolina, September 4, 2025
News Summary
PL Developments, a New York-based pharmaceutical manufacturer, announced it will lay off 114 employees at its Piedmont facility by the end of October 2025. This decision is part of restructuring efforts aimed at enhancing operational efficiency due to a nationwide decline in consumer demand. Despite the layoffs, the company will create 50 new jobs for a weekday third shift, offering affected workers the chance to apply for these positions. The factory has been operational since 2017 and focuses on first aid products.
Piedmont, South Carolina: PL Developments to Lay Off 114 Workers
PL Developments, a New York-based manufacturer of over-the-counter pharmaceuticals, has announced plans to lay off 114 employees at its Piedmont factory by the end of October 2025. This decision comes as part of the company’s ongoing restructuring efforts aimed at improving operational efficiency.
The company issued a notification regarding the layoffs on August 29, in compliance with the South Carolina WARN Act, which mandates advanced notice for substantial job cuts. This marks the second round of layoffs for PL Developments within South Carolina in less than a year, following earlier reductions that affected 113 workers at its Clinton factory in January 2025.
Charles Cain, the general counsel and chief administrative officer for PL Developments, highlighted that the layoffs are a response to an overall decline in consumer demand impacting pharmaceutical manufacturers nationwide. However, the company continues to report strong demand for its core products, particularly first aid items produced at the Piedmont facility.
Operational Changes and Future Outlook
In addition to the layoffs, PL Developments has announced the elimination of weekend shifts at the Piedmont factory. However, the company plans to hire 50 new employees for a weekday third shift, allowing affected workers the option to apply for these new positions. Cain pointed out that weekend shifts could potentially resume if consumer demand rebounds in early 2026.
The Piedmont factory, which commenced operations in 2017, occupies a 200,000 square-foot facility located off U.S. Route 25 near Interstate 185. PL Developments manufactures a diverse range of over-the-counter products, including various first aid items, which are sold under private labels or store brands. Despite the recent layoffs, the company has made considerable investments to expand capacity and enhance productivity, not only at the Piedmont facility but also at another factory in California.
Company Background
When PL Developments opened the Piedmont factory, the company aimed to invest around $45 million and create approximately 450 jobs in the region. Apart from the factory, the company operates two distribution centers located off Interstate 85 in Spartanburg County, South Carolina.
These strategic decisions—layoffs, operational shifts, and investments—reflect the broader trends within the pharmaceutical industry, challenging manufacturers to adapt to fluctuating consumer preferences while maintaining production capabilities.
FAQ
What is the reason for the layoffs at PL Developments?
The layoffs are attributed to company restructuring efforts aimed at improving machine efficiency, alongside a broader decline in consumer demand affecting pharmaceutical manufacturers nationwide.
How many workers will be affected by the layoffs?
A total of 114 workers at the Piedmont factory will be laid off by the end of October 2025.
Will there be any new job opportunities following the layoffs?
Yes, PL Developments plans to create 50 new positions for a weekday third shift, and affected workers will have the option to reapply for these positions.
What products does the Piedmont factory produce?
The Piedmont factory produces a variety of over-the-counter products, with a focus on first aid items which are distributed under private and store brands.
Key Features of PL Developments Layoff Announcement
| Feature | Details |
|---|---|
| Layoff Count | 114 Workers |
| Factory Location | Piedmont, South Carolina |
| Announcement Date | August 29, 2025 |
| Reason for Layoffs | Restructuring for machine efficiency and declining consumer demand |
| New Job Opportunities | 50 positions for weekday third shift |
| Factory Opening Year | 2017 |
| Investment and Job Creation Goals | $45 million investment and 450 jobs |
Deeper Dive: News & Info About This Topic
HERE Resources
High School Football Season Kicks Off in South Carolina
Qatar Airways Signs Major Deal with Boeing
Qatar Airways Partners with Boeing for Major Jet Purchase
State Department Employees Prepare for Layoffs
Tesla’s Robotaxi Service Launching in San Francisco Bay Area
Qatar Airways and Boeing Sign Landmark Jet Purchase Agreement
Lockheed Martin Layoffs Impact 180 Workers in Greenville, SC
Harvard University Challenges Trump Administration Over International Students
CEF Solutions Inc. to Lay Off Employees in Greenville County
Trump Doubles Tariffs on Steel and Aluminum
Additional Resources
- Post and Courier: PL Developments Layoffs
- WXII12: Panera Bread and IBM Layoffs
- MyFox8: IBM Layoffs Impact
- WCNC: Piedmont Lithium Layoffs
- Reuters: Piedmont Lithium Job Cuts
- Wikipedia: Piedmont, South Carolina
- Google Search: Pharmaceutical Manufacturing Layoffs
- Google Scholar: Pharmaceutical Industry Layoffs
- Encyclopedia Britannica: Pharmaceutical Industry
- Google News: Manufacturing Layoffs 2025

Author: STAFF HERE GREENVILLE
The HERE Greenville Staff Writers are a collaborative team of journalists, editors, and local contributors passionate about delivering accurate, timely information to the Greenville community. As part of the HEREcity.com Network, which powers over 100 U.S. city sites including HEREcolumbia.com, our staff draws on collective experience in South Carolina journalism to cover everything from business sales and real estate developments to dining deals and community initiatives. Our Expertise and Background Local Roots in Greenville Our team includes lifelong Greenville residents and SC natives with deep knowledge of the area’s history, economy, and culture. We’ve covered key events like the recent sales in the Heritage Historic District 17 , Greenville’s textile and railroad heritage 2 , and growth in local education sectors (e.g., Greenville Technical College programs) 27 . Collective Experience With over 50 combined years in journalism, our staff has backgrounds in print, digital media, and community reporting. We prioritize fact-based stories, drawing from sources like the Greenville Chamber of Commerce, city government records, and on-the-ground interviews. Commitment to Quality Every article is a group effort, involving research, editing, and verification to ensure reliability. We adhere to journalistic standards, citing credible sources and updating content as new details emerge.


